Amodis 400 is a high-potency antimicrobial and antiprotozoal medication containing Metronidazole used for the effective treatment of infections caused by anaerobic bacteria and parasites. It belongs to the nitroimidazole class of drugs and works by interacting with microbial DNA to disrupt its synthesis, causing cellular death in targeted pathogens. Produced by Square Pharmaceuticals PLC, here is an updated guide for 2026.
What is Amodis 400 Used For?
Amodis 400 contains 400 mg of Metronidazole and is primarily prescribed for:
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Amoebiasis and Giardiasis: Eradication of parasitic intestinal infections that cause acute diarrhea, severe stomach cramping, and amoebic liver abscesses.
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Anaerobic Bacterial Infections: Treatment of deep-tissue infections including intra-abdominal sepsis, pelvic abscesses, peritonitis, and post-operative wound complications.
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Gynecological Infections: Management of bacterial vaginosis and urogenital trichomoniasis in adult patients.
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Dental Infections: Rapid control of acute dental abscesses and acute ulcerative gingivitis (severe gum inflammation).
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Surgical Prophylaxis: Prevention of potential post-operative anaerobic bacterial infections before major abdominal or gynecological surgeries.
Clinical research highlights metronidazole’s broad-spectrum bactericidal activity against strict anaerobes. For a deeper look at its clinical profile, see this StatPearls Clinical Review on Metronidazole.
Dosage
For adults and children over 10 years of age, the standard dosage ranges from 400 mg to 800 mg taken two to three times daily, depending entirely on the type and severity of the target infection.
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Administration: The tablet should be swallowed whole with a glass of water. Do not crush or chew it.
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Timing: It must be taken with or immediately after food to lower the risk of gastrointestinal irritation.
Common Side Effects
Amodis 400 is well-tolerated by most individuals when taken as directed. Because it interacts with metabolic pathways in the digestive tract, localized gastrointestinal signs are standard. Potential mild side effects include:
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An unpleasant metallic taste in the mouth or furred tongue
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Nausea, vomiting, or minor appetite loss
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Diarrhea, flatulence, or abdominal discomfort
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Mild headache or transient dizziness
Safety Insight: While highly effective, completing the full course as prescribed is necessary to prevent microbial mutation. For more peer-reviewed information on its safety and cellular profile, refer to this NCBI PMC Research Study on Nitroimidazole Antimicrobials.
Important Warnings & Precautions
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Strict Alcohol Warning: Do not consume alcohol during therapy and for at least 48 hours after your final dose. Combining Metronidazole with alcohol triggers a disulfiram-like reaction, causing severe nausea, vomiting, facial flushing, rapid heart rate, and throbbing headaches.
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Neurological Monitoring: Discontinue the drug immediately and consult your physician if you experience any signs of peripheral neuropathy, such as numbness, tingling, or muscle weakness.
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Blood Discrepancies: Use with caution in patients with a known history of blood dyscrasias, as mild, reversible leucopenia (low white blood cell count) has been observed with prolonged use.
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Pregnancy/Breastfeeding: Listed under US FDA Pregnancy Category B. It should be avoided during the first trimester unless deemed absolutely vital by a physician. Breastfeeding should be paused during treatment and resumed 48 hours after the final dose.
Price in Bangladesh (January 2026 Approximate)
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Price per Tablet: Approximately ৳1.70.
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Price per Strip (10 Tablets): Typically ৳17.00.
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Manufacturer: Square Pharmaceuticals PLC.
Frequently Asked Questions (FAQ) About Amodis 400
Q: What is Amodis 400 used for?
Amodis 400 is primarily indicated for treating parasitic gut infections (amoebiasis, giardiasis), anaerobic bacterial infections, bacterial vaginosis, and deep dental abscesses. As detailed in peer-reviewed medical databases, its reduced active form binds to microbial DNA to completely arrest replication pathways.
Q: Is Amodis 400 an antibiotic?
Yes. It is an antimicrobial and antiprotozoal medication formulated to eliminate anaerobic bacterial and parasitic infections. It does not treat viral conditions.
Q: Amodis 400 dose per day
The standard adult daily dosage usually ranges from 400 mg twice daily to 800 mg three times daily, based on the specific type of infection. Official medical guidelines emphasize taking it with a solid meal to minimize nausea.
Q: Amodis 400 price in Bangladesh
As of 2026, the Amodis 400 price in Bangladesh is approximately ৳১.৭০ per tablet. The retail market price in local pharmacies averages ৳১৭.০০ for a ten-tablet strip.
Q: Is Amodis good for a cough?
No. Amodis 400 acts selectively on anaerobic bacteria and protozoa. Peer-reviewed studies confirm it has no antitussive properties and cannot treat dry or productive coughs brought on by common colds or respiratory viruses.
Q: Does Amodis 400 make you sleepy?
While mild drowsiness or dizziness can occur as rare side effects in sensitive individuals, Amodis 400 is not a primary sedative. Most users complete their therapeutic courses without severe drowsiness.
Q: Amodis 400 side effects
Possible Amodis 400 side effects include a sharp metallic taste, mild nausea, stomach upset, or dark-colored urine. According to FDA Drug Safety Reviews, these symptoms are entirely temporary and resolve naturally after the medication course is finalized.
Q: How quickly does Amodis 400 start working?
It is absorbed rapidly by the digestive tract, reaching peak concentration in the blood within 1 to 2 hours, though observable improvements in gastrointestinal or systemic symptoms can take 24 to 48 hours.
Q: Are there any alternatives to Amodis 400 in Bangladesh?
Yes. Common alternatives include Flagyl 400 (Synovia/Sanofi), Filmet 400 (Beximco), Metryl 400 (Opsonin), Metro 400 (Ziska), and Dirozyl 400 (ACME).
Q: Does Amodis 400 treat the common cold?
No. Amodis 400 targets specific microscopic parasites and anaerobic bacteria. It offers zero therapeutic efficacy or clinical defense against common viral cold strains or seasonal influenza.
Q: What if I miss a dose?
Take it as soon as you remember with food, unless it is almost time for your next scheduled interval. Never take a double dose to compensate for a missed tablet.
Q: How to reduce household allergy triggers?
Minimize dust and allergens by using an easy-to-clean sofa or a high-quality bed.
Disclaimer: This is educational information only (updated January 2026). Not a substitute for professional medical advice. Always consult a qualified physician before starting or stopping any medication.
